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PSMA Therapy in Metastatic prostate

Lu-177-PSMA treatment for metastasized prostate danger

Preconditions before Lu-177 PSMA treatment

Lu-177 PSMA treatment is available for patients with tumors with satisfactory PSMA take-up that are progressing under attested treatment decisions (hormone treatment, outside radiation treatment or chemotherapy). Before Lu-177-PSMA-DKFZ-617 treatment can be performed, PSMA take-up and the sign to execute the treatment must be imagined by PSMA PET/CT (standard system at our subject matter). Despite further necessities which the treating authorities will solely review before a Lu-177 PSMA treatment, renal limit and bone marrow work must be inside certain purposes of repression. As a rule, further tests (for instance kidney work scintigraphy, inquire about focus tests and others) are required, which all can be performed at our deparment.

How is the treatment performed?

Treatment is performed on an in-calm reason at our treatment ward K0. The treatment itself takes around 15 minutes (blend). Due to the non-target take-up of Lu-177 PSMA in the salivary organs, the patients should apply cold packs 30 minutes prior and up to 4 hours after treatment, to cool the salivary organs and as such diminishing blood scattering. Thusly, a lesser centralization of radioactivity in the salivary organs is ordinary. To foresee mischief to the kidneys, i.v. blends will be given explicitly already, in the midst of and after treatment. Furthermore, upon the entry of treatment and the days after, satisfactory take-up of liquid is endorsed to decrease radiation part to the kidneys and the body. The treatment generally requires a multi day hospitalization.

After treatment, the treatment unit may not be left for 48 hours. After discharge, lab control of the blood, liver and kidney regards after approx. 2 and a month and a half is required. This should be conceivable at home by the GP, urologist or oncologist.

All things considered, no under 2 treatment cycles (by and large 4) in a multi week interval will be performed. To overview the treatment response similarly as manifestations and troubles, ensuing meet-ups in ordinary time intervals (for instance PET/CT, kidney scintigraphy) will be performed. On the off chance that there ought to be an event of good response or modification of the sickness and further extraordinary amassing in PSMA ligand PET/CT, further treatment cycles can be performed in case of good bone marrow and kidney work.

Perplexities and manifestations of treatment

The results to date exhibit that no material outrageous extreme troubles are viewed. In any case, paying little mind to persisting thought, the Lu-177 PSMA treatment may include manifestations and burdens. Since the treatment is an individualized treatment with an unapproved sedate, in the past cloud threats, responses and complexities can’t be totally precluded.

The going with responses and troubles are before long known:

General side effects and perplexities:

Fever after treatment

Speculatively, ominously defenseless reactions in the midst of association of the treatment substance, up to a touchy shock, may occur (in any case, this has never been looked for this treatment)

Nausea, regurgitating and nonappearance of wanting

Every so often slight loss of hair in the midst of the weeks after treatment

Remarkable cases report change of taste after RLT has been represented

Tiredness and depletion (up to a large portion of a month after RLT)

Basic lead for patient:

Upon the landing of treatment, a couple of liters of liquid should be flushed, to hold the part to the kidneys and the radiation pile of whatever remains of the body as low as could be permitted (enlivened release).

The salivary organs should be cooled by infection packs approx. 30 minutes going before and up to 4 hours after treatment to as such decrease the circulation system. This ought to cut down the gathering of radio-development in the salivary organs.

In the midst of the in-comprehension remain, you are disastrously not allowed any visitors on the treatment unit K0. Just in incredible cases and after prior insight with your pro you can be allowed to leave the unit in the midst of the underlying 48 h after treatment.

After discharge, your relatives don’t have to fear any perilous radiation shot.

On the off chance that it’s not all that much inconvenience immediately prompt your master if you experience any appearances, irrelevant of kind and graveness.

After treatment, the treatment unit may not be left for 48 hours. After release, research facility control of the blood, liver and kidney esteems after approx. 2 and a month and a half is required. This should be possible at home by the GP, urologist or oncologist.

For the most part, no under 2 treatment cycles (normally 4) in a multi week interim will be performed. To survey the treatment reaction just as symptoms and confusions, subsequent meet-ups in normal time interims (for example PET/CT, kidney scintigraphy) will be performed. If there should be an occurrence of good reaction or adjustment of the sickness and further great stockpiling in PSMA ligand PET/CT, further treatment cycles can be performed if there should arise an occurrence of good bone marrow and kidney work.

Difficulties and reactions of treatment

The outcomes to date demonstrate that no significant serious intense difficulties are watched. Notwithstanding, in spite of tenacious consideration, the Lu-177 PSMA treatment may involve reactions and intricacies. Since the treatment is an individualized treatment with an unapproved medicate, once in the past obscure dangers, symptoms and inconveniences can’t be completely rejected.

The accompanying symptoms and intricacies are by and by known:

General symptoms and intricacies:

  • Fever after treatment
  • Hypothetically, unfavorably susceptible responses amid organization of the treatment substance, up to a hypersensitive stun, may happen (in any case, this has never been watched for this treatment)
  • Queasiness, spewing and absence of hunger
  • Once in a while slight loss of hair amid the weeks after treatment
  • Uncommon cases report change of taste after RLT has been accounted for
  • Tiredness and exhaustion (up to half a month after RLT)

Imperative conduct for patient:

  • Upon the arrival of treatment, a few liters of fluid ought to be tanked, to hold the portion to the kidneys and the radiation heap of the rest of the body as low as could be allowed (quickened discharge).
  • The salivary organs ought to be cooled by virus packs approx. 30 minutes before and as long as 4 hours after treatment to along these lines decrease the blood stream. This should bring down the convergence of radio-action in the salivary organs.
  • Amid the in-quiet remain, you are lamentably not permitted any guests on the treatment unit K0. Just in excellent cases and after earlier interview with your specialist you can be permitted to leave the unit amid the initial 48 h after treatment.
  • After release, your relatives don’t need to fear any risky radiation hazard.
  • It would be ideal if you quickly illuminate your specialist on the off chance that you experience any indications, insignificant of kind and graveness.